Watch Prison Break S04e21 1 (2025)

Availability varies significantly by region, so check your local catalog.

After being captured and tortured by federal agents for information on the brothers, Don Self is left in a vegetative state after the General’s men inject him with a debilitating chemical to keep him quiet. Where to Watch Watch Prison Break S04E21 1

Michael manages to orchestrate a rescue for Sara, appearing just in time to stop T-Bag from assaulting her. Meanwhile, Mahone—appearing to betray Michael—strikes a deal with Christina to bring her Scylla in exchange for his wife's safety, though this is part of a deeper ruse involving a bomb. Availability varies significantly by region, so check your

In many international markets (via the Star hub), Prison Break is part of the standard library. C-Note reveals he is working with a mysterious

C-Note and Sucre reunite in Chicago. C-Note reveals he is working with a mysterious benefactor (later revealed to be Paul Kellerman) who claims he can help the brothers gain total immunity if they can provide Scylla.

Christina Rose Scofield (Michael’s mother) holds Lincoln hostage, while the General (Jonathan Krantz) holds Sara. Michael must decide who to trade the real Scylla for, leading to a complex multi-front game of leverage.

The episode is available for individual purchase or as part of Season 4 on platforms like Amazon Prime Video, Apple TV, and Google Play. "Prison Break" Rate of Exchange (TV Episode 2009) - IMDb