The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions
Structure and function of otoferlin, a synaptic protein of ... - PMC
Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. tm,cc,jp
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").
ions are bound per domain, with specific significance for the . The protein utilizes several C2 domains (C2A-C2F) to
The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, - PMC Sensing: The C2D domain is identified
The study highlights that membrane binding involves a cooperative effort of multiple domains.