: The story takes place in a dystopian future where humanity has spread across the solar system under the rule of the Eusan Nation. Society relies on Replikas —androids modeled after human "gestalts" (original human minds).

It does mean the game is related to the Darksiders action-adventure series, which follows the Four Horsemen of the Apocalypse .

Signalis is a psychological horror game heavily inspired by Classic Resident Evil and the cosmic horror of H.P. Lovecraft.