For missions requiring you to "hit no mines," you can stay safely behind an obstacle and wait for the timer to run out to complete the goal. Combo & Score Management
In levels where pickups rotate, you will gather significantly more items by moving against the rotation rather than following it. Sexy Exile
Hitting a mine causes a massive combo loss, which can lead to mission failure on harder difficulties. It is often safer to miss a few hearts than to risk a mine hit. For missions requiring you to "hit no mines,"
For missions requiring big hearts while controls are inverted, Nikki 2-7 is the most efficient choice, yielding roughly 75 hearts per try. yielding roughly 75 hearts per try.