[s5e22] What A Difference A Day Makes -

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation.

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex. [S5E22] What a Difference a Day Makes

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. While the wedding takes center stage, the hospital