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: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes

This paper examines the two-part Season 4 finale of House, M.D. , comprising the episodes "" (S4E15) and " Wilson’s Heart " (S4E16). It explores how the narrative utilizes a traumatic bus crash to deconstruct Gregory House’s psyche, the fragility of memory, and the "cosmic unfairness" of life. The Quest for Memory

: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure

In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure.