: Luffy discovers Ace is currently being held at the world’s greatest underwater prison, Impel Down. He decides to delay finding his crew to rescue his brother first. Key Developments
, titled "Rescue Ace! The New Destination is the Great Prison" , is a pivotal turning point in the Amazon Lily Arc, marking the moment Monkey D. Luffy shifts his focus from reuniting with his crew to saving his brother. Episode Summary One Piece Episode 416
: At the end of the episode, Hancock falls ill with a mysterious "heartache," which Elder Nyon identifies as "Love Sickness" because she has fallen for Luffy. : Luffy discovers Ace is currently being held