This season shifts focus toward Peter Parker leading a new team of S.H.I.E.L.D. academy students to take down a reconstituted Sinister Six. Key highlights and features of this season include:
: The season heavily features the "Spider-Verse," introducing or bringing back various versions of Spider-Man, including Miles Morales (Kid Arachnid), Scarlet Spider, and Spider-Woman (Mary Jane Watson).
: Doctor Octopus returns to form a new version of the villainous group, leading to a season-long overarching conflict.