: House’s team (Chase, Cameron, and Foreman) is stymied. Because they are monozygotic triplets, any genetic defect should be present in all three. However, their bodies are reacting differently to the same environment.
: House treats them as a single organism with three different "outputs." He theorizes that while their DNA is the same, their epigenetics —how those genes are expressed—have diverged due to secret lifestyle differences. Dr. House: 2Г—3
The episode opens with three identical 19-year-old sisters—Maya, Lea, and Chloe—admitted to Princeton-Plainsboro. They were performing a synchronized gymnastics routine when Maya went into respiratory failure, Lea suffered a seizure, and Chloe remained perfectly fine—until she began experiencing "sympathetic" pain so intense it mimicked a heart attack. The Investigation : House’s team (Chase, Cameron, and Foreman) is stymied
had a delayed reaction that eventually triggered a cytokine storm. The Resolution : House treats them as a single organism
House discovers that the sisters were all taking a specific "natural" performance-enhancing supplement to stay thin for gymnastics. Because of a rare phenomenon in female development (skewed X-inactivation), each sister's body processed the supplement's toxins differently: