After defeating the Spider Mastermind, the Slayer is pulled back to Mars by Hayden. Hayden betrays him, admitting that while the invasion was a disaster, humanity still needs Argent energy. He takes the Crucible from the Slayer and transports him to an unknown location, setting the stage for the sequel, Doom Eternal .

: The Slayer confronts Olivia Pierce at the source of the portal. She is sacrificed by the demons and transformed into the Spider Mastermind , whom the Slayer destroys. The Ending and Betrayal

While the game is famous for its fast-paced "push-forward combat", it features a deep narrative regarding the energy crisis on Earth and the lengths to which the Union Aerospace Corporation (UAC) went to solve it.