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This research investigates how budding yeast cells adapt to the loss of Ctf4 , a protein critical for coordinating DNA replication. The study identifies specific evolutionary pathways—including mutations in the cohesion, replication, and checkpoint modules—that allow cells to restore fitness despite constitutional DNA replication stress .

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Authors: Fumasoni M, Murray AW. Publication: eLife , 2020. Read the full article at eLife . This research investigates how budding yeast cells adapt