Active caspase-8 was found to be significantly increased in the brain tissue of human MS patients, suggesting this pathway is a potential target for new MS therapies. 2. Engineering & Heat Transfer: Serpentine Cooling Channels
The study reveals that a specific protein complex (IRAKM–caspase-8–ASC) forms in the brain's immune cells (microglia) when stimulated. This leads to the release of inflammatory cytokines like IL-1β, which drives the progression of CNS inflammation and MS symptoms. 121901
Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE) . Active caspase-8 was found to be significantly increased
In the field of mechanical engineering, 121901 refers to a study on serpentine cooling channels published in the Journal of Heat Transfer . This leads to the release of inflammatory cytokines
The study provides a blueprint for designing more efficient cooling systems for high-temperature machinery. 3. Renewable Energy: Wave Energy Converters
The sequence is also assigned to several other technical papers in physics and materials science:
In the journal Renewable Energy , article 121901 investigates Oscillating Water Column (OWC) arrays . Capturing energy from ocean waves.